• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >A randomised, double-blind, placebo-controlled, cross-over pilot study to assess the effects of long-term opiod drug consumption and subsequent abstinence in chronic non-cancer pain patients receiving controlled-release morphine
【2h】

A randomised, double-blind, placebo-controlled, cross-over pilot study to assess the effects of long-term opiod drug consumption and subsequent abstinence in chronic non-cancer pain patients receiving controlled-release morphine

机译：一项随机，双盲，安慰剂对照，交叉试验研究，旨在评估长期服用鸦片类药物和随后戒断对接受控制释放吗啡的慢性非癌性疼痛患者的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives. The long-term use of strong opioid analgesics among chronic noncancer pain (CNCP) patients remains controversial because of concerns over problematic drug use. However, previous surveys suggest that this is not necessarily the case. Therefore, we designed a controlled study to generate evidence in support of these findings. Patients/Setting. Ten CNCP patients attending the pain clinic in a district general hospital had been taking an average daily dose of 40 mg controlled-release morphine sulphate (mean 40, range 10-90, SD 21 mg), for an average of 2 years (mean 2.175, range 2-2.25, SD 0.2 years). Design. Randomized, double-blind, placebo controlled cross-over study. The study was based on the premise that abrupt cessation of opioid drugs is most likely to highlight problematic use and the consequent inability to stop using opioids. Morphine was substituted with placebo for 60-hour periods to compare the effects of abstinence with those of continued use. Assessment of morphine cessation and abstinence effects was through direct observation, physiological measurements, questionnaire responses, and Brief Pain Inventory scores. Results. Following cessation and abstinence, there were no indications of psychological dependence or drug craving, but there was evidence of the detrimental effects of pain intensity on activity, mood, relationships, sleep, and enjoyment of life. Three patients (30%) reported opioid drug withdrawal symptoms. Pharmacokinetic data demonstrated compliance with abstinence by all patients. Conclusion. The results suggest the existence of a group of CNCP patients whose long-term opioid consumption can be beneficial and remain moderate without them suffering from the consequences of problematic opioid drug use
机译：目标。由于担心药物使用问题，在慢性非癌性疼痛（CNCP）患者中长期使用强效阿片类镇痛药仍存在争议。但是，以前的调查表明情况并非一定如此。因此，我们设计了一项对照研究，以产生支持这些发现的证据。患者/设置。在地区综合医院疼痛诊所就诊的10名CNCP患者平均每日服用40毫克硫酸吗啡控释药物（平均剂量40，范围10-90，标准剂量21毫克），平均服用2年（平均剂量2.175） ，范围2-2.25，SD为0.2年）。设计。随机，双盲，安慰剂对照的交叉研究。这项研究是基于这样的前提，即突然停止使用阿片类药物可能会突出使用问题，并因此导致无法停止使用阿片类药物。将吗啡用安慰剂替代60小时，以比较禁欲与持续使用的效果。通过直接观察，生理测量，问卷调查和简短疼痛量表评分来评估吗啡戒断和禁欲作用。结果。戒烟和戒酒后，没有任何心理依赖或药物渴望的迹象，但有证据表明，疼痛强度对活动，情绪，人际关系，睡眠和生活乐趣产生有害影响。三名患者（30％）报告了阿片类药物停药症状。药代动力学数据表明所有患者均符合禁欲。结论。结果表明，存在一组长期服用阿片类药物可能有益且保持中度状态的CNCP患者，而不会遭受阿片类药物使用问题的后果

著录项

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号